Traditional uses, nutritional properties, phytochemical metabolites, pharmacological properties, and potential applications of Lilium spp.: a systematic review

作者：Zhichao Wang, Huan Chen, Pucheng Feng, De Yun Wang, Xiaoquan Du · 发表于：Frontiers in Pharmacology · 年份：2025 · DOI：10.3389/fphar.2025.1713957 · 被引用次数：8 · 研究领域：Phytochemical Studies and Bioactivities、Flowering Plant Growth and Cultivation、Chemical synthesis and alkaloids

Introduction Lilium spp., perennial bulbous plants native to the Northern Hemisphere, have long been valued in traditional medicine, particularly across Asia. The bulbs of Lilium brownii (“Bai He” in traditional Chinese medicine) have been documented since the Han dynasty as both food and medicine to nourish yin, moisten the lungs, clear heart fire, and calm the spirit—traditionally used for conditions such as depression and diabetes. Contemporary research has increasingly validated these traditional claims, revealing diverse pharmacological activities including antidepressant and antitumor effects. Methods A comprehensive literature review was conducted using databases including Web of Science, PubMed, ACS Publications, Google Scholar, Baidu Scholar, and CNKI, as well as the Encyclopedia of Life , Flora of China , and Plants of the World Online . Taxa recorded in the Chinese Pharmacopoeia (2025) were included: Lilium lancifolium Thunb., Lilium brownii F. E. Brown var. viridulum Baker, and Lilium pumilum DC, and related species. All relevant multilingual publications were critically evaluated and accurately cited. Chemical structures of isolated metabolites were visualized using ChemDraw v19.0. Results Lilium spp. are consumed in various culinary and processed forms, including steamed bulbs, flour, wine, and functional beverages. Nutritionally, they are rich in polysaccharides, saponins, dietary fibers, vitamins, amino acids, starch, pectin, phospholipids, and essential miner...