pH calibration allows accurate glucose detection in interstitial fluid via reverse iontophoresis

作者：Wangwang Zhu, Haixia Yu, Wen‐Jun Li, Xi Li, Hao Zheng, Chengcheng Li, Xingguo Zhang, Chenxi Jin, Mutian Wang, Jiaqi Hou, Youhao Liu, Yuxiao Ma, Zhongxu Zhou, Miao Deng, Peng Guo, Mingzhen Li, Zhenqiang Song, Zhihua Pu, Dachao Li · 发表于：Nature Communications · 年份：2025 · DOI：10.1038/s41467-025-65453-0 · 被引用次数：10 · 研究领域：Advancements in Transdermal Drug Delivery、Advanced Sensor and Energy Harvesting Materials、Microfluidic and Capillary Electrophoresis Applications

movement and the skin recovery ability. Here, we investigated how the skin surface pH affected RI, theoretically and experimentally; and developed a wearable device and a calibration method to enable accurate non-invasive ISF glucose detection, accordingly. The result showed that glucose prediction accuracy was markedly improved, with mean absolute relative difference (MARD) decreased from 34.44% to 14.78% across both healthy and diabetic volunteers.