Trends and disparities in mortality associated with peripheral artery disease and hyperlipidemia, 1999–2024

作者：Saifullah Khan, Muhammad Hassan, Muhammad Hussain, Hassan Abdul Aziz Dhedhi, Wania Fatima, Javeria Nawaz, Aiza Ahsan, Flávia Q. Pirih, Nisha Khalid, Mariam Qaisar, Ahmad Anees Qureshi, Mariam Baig, Sherif Eltawansy, Muhammad Khalid Afridi, Preet Memon, Shoaib Waqas, Gregg C. Fonarow, Raheel Ahmed, Hasibullah Aminpoor · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-29224-7 · 被引用次数：5 · 研究领域：Peripheral Artery Disease Management、Cerebrovascular and Carotid Artery Diseases、Renal and Vascular Pathologies

Peripheral artery disease (PAD) with hyperlipidemia adds significantly to the national burden of cardiovascular disease. However, population-level trends in mortality for these conditions are not well understood. We used nationally representative data to investigate long-term temporal patterns and disparities in PAD and hyperlipidemia related mortality in the United States. This descriptive analysis analyzed death records from the CDC WONDER database from 1999 to 2024. The age-adjusted mortality rates (AAMRs) per 100,000 people were calculated for each demographic and geographic strata. AAMRs were standardized to 2000 U.S. standard population. Temporal trends in AAMRs were analyzed using Joinpoint regression to estimate the average annual percent change (AAPC) with 95% confidence intervals (CIs) and p value. Between 1999 and 2024, a total of 148,416 PAD with hyperlipidemia-related deaths were recorded among U.S. adults ≥ 25 years. The national AAMR rose from 0.74 in 1999 to 3.92 in 2024, corresponding to an overall AAPC of 6.32. Both sexes experienced increasing mortality, though men had higher rates and faster growth compared with women. By race/ethnicity, AAMRs increased across all groups, with the steepest relative rise among Hispanic individuals, followed by Non-Hispanic (NH) Black, NH White, and NH Asian or Pacific Islander populations. Geographic disparities were observed, with state-level AAMRs ranging from 0.92 in Georgia to 5.06 in Vermont, and the highest regional m...