Framework Nucleic Acids Nanoplatform Regulating Cellular Stemness and Oxidative Microenvironment for Synergistic Treatment of Ocular Surface Disorders (Adv. Funct. Mater. 46/2025)

作者：Manli Deng, Zhongxing Chen, Xiaomin Huang, Aodong Chen, Jiawei Li, Wei Wang, Qingyi Gao, Lingxin Chen, Qianfang Ye, Yue Wu, Jun Zou, Mei Yang, Bowen Tan, Zi‐Jian Li, Lin Xu, Xingtao Zhou, Xiaoying Wang, Jinhai Huang · 发表于：Advanced Functional Materials · 年份：2025 · DOI：10.1002/adfm.72428 · 研究领域：Corneal Surgery and Treatments、Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis

Framework Nucleic Acids Nanoplatform In their Research Article (10.1002/adfm.202508302), Xingtao Zhou, Xiaoying Wang, Jinhai Huang and co-workers develop a framework nucleic acids (FNAs)-based nanoplatform for the synergistic treatment of corneal alkali burns. The framework nucleic acids (FNAs) are developed to load L-ascorbic acid 2-phosphate (AA2P) with high loading capacity. The resulting FNAs-AA2P significantly inhibits the oxidative stress, mitochondrial membrane potential abnormality, and apoptosis of corneal epithelial progenitor cells (TKE2) under alkali conditions in vitro. Furthermore, FNAs-AA2P regulates the expression of critical markers associated with enhanced proliferation and stemness of TKE2 cells.