Quality of Life and Treatment Satisfaction in People with HIV Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Pooled Analysis from Observational Cohort Studies

作者：Andrea Antinori, Yoshiyuki Yokomaku, Hila Elinav, Hüsnü Pullukçu, Joss de Wet, Antonio Antela, Po‐Liang Lu, Michael Sabranski, Yeon-sook Kim, Fabrice Bonnet, Jan den Hollander, Arthur Jackson, Chiaw Yee Choy, Weiping Cai, Fujie Zhang, David Thorpe, Andrea Marongiu, Rebecca Harrison, James Jarrett, Marta Boffito · 发表于：Infectious Diseases and Therapy · 年份：2025 · DOI：10.1007/s40121-025-01252-w · 被引用次数：3 · 研究领域：HIV/AIDS drug development and treatment、HIV-related health complications and treatments、HIV/AIDS Research and Interventions

INTRODUCTION: Patient-reported outcomes (PROs) provide important insights into individuals' health and well-being. We report PROs from six observational cohort studies in treatment-experienced people with HIV switching to bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in routine clinical practice. METHODS: Data were pooled from the BICtegravir Single Tablet Regimen (BICSTaR) cohort studies (Asia/Canada/EU/Israel/Japan) and a similarly designed Chinese cohort study (GS-CN-380-5759). Quality of life (QoL; mental/physical health) and HIV treatment satisfaction were self-reported by participants using the generic (non-HIV-specific) 36-item Short Form Health Survey questionnaire and HIV Treatment Satisfaction Questionnaire (HIVTSQ; status [s]/change), respectively. Descriptive statistics and linear mixed models adjusted for potential confounders and interactions, with bootstrapped confidence intervals, were used to analyse PROs through 24 months (12 months for treatment satisfaction). RESULTS: Of 3724 treatment-experienced participants included, 64.2% were Asian, 89.0% male; median age was 41 years. Baseline Mental Component Summary (MCS) scores were below the population average despite receiving antiretroviral therapy, whereas Physical Component Summary (PCS) scores were above average. At 24 months, observed median MCS score improved from baseline (+ 0.6 [interquartile range [IQR] - 4.3 to + 5.9; p = 0.018]) and median PCS score remained stable (- 0.1 [IQR - 3.3 to + 3...