Intratumoral microbiota-derived S1P sensitizes the combination therapy of capecitabine and PD-1 inhibitors

作者：Chen-Shu Dai, Tiantian Qi, Hui-Ling Shang, Ri‐hua Xie, Hao Liu, Zhenming Liu, Cui Yi-min, Yu-Hang Zhang · 发表于：iScience · 年份：2025 · DOI：10.1016/j.isci.2025.114202 · 被引用次数：2 · 研究领域：Cancer Immunotherapy and Biomarkers、Immune cells in cancer、Sphingolipid Metabolism and Signaling

T cell expansion and exhausted T cell subset reduction within TME. To conclude, these findings highlight microbial sphingolipids as potential predictive biomarkers for strategies of targeting intratumoral microbiota in CRC management.