Association of the CHG index with 90-day functional outcomes and mortality in acute ischemic stroke after endovascular therapy: A retrospective study

作者：Chuang Yang, Mengmeng Ma, Xin Jiang, Lidan Zhang, Yang Zhang, Muke Zhou, Li He, Jinghuan Fang · 发表于：Journal of Stroke and Cerebrovascular Diseases · 年份：2025 · DOI：10.1016/j.jstrokecerebrovasdis.2025.108502 · 被引用次数：3 · 研究领域：Acute Ischemic Stroke Management、Moyamoya disease diagnosis and treatment、Intracerebral and Subarachnoid Hemorrhage Research

BACKGROUND AND PURPOSE: No prior study has investigated the potential of the cholesterol, high-density lipoprotein, and glucose (CHG) index as a predictor of clinical outcomes in patients with acute ischemic stroke (AIS) undergoing endovascular treatment (EVT). This study aimed to assess the effect of the CHG index on functional prognosis and build a better predictive model. METHODS: We retrospectively analyzed AIS patients receiving EVT between January 2016 and March 2025. The primary outcome was poor functional outcome, defined as a modified Rankin scale (mRS) score of 3 - 6 at 90 days. Logistic regression and restricted cubic splines (RCS) were used to examine the relationship between the CHG index and clinical outcomes. Receiver operating characteristic (ROC) curve was constructed to evaluate the prognostic capacity of the CHG index. RESULTS: A total of 934 patients were included. Logistic regression analysis indicated that a higher CHG index was associated with worse functional outcome at 90 days and increased 90-day mortality. A RCS model revealed a linear association between the CHG index and poor outcome at 90 days, symptomatic intracerebral hemorrhage (sICH), and 90-day mortality. In ROC curve analysis, the predictive ability of the traditional risk factor model was significantly enhanced by incorporating the CHG index for poor outcome at 90 days and for mortality at 90 days. CONCLUSION: In patients with AIS undergoing EVT, a higher CHG index was associated with poor...