PPARδ-87T/C plays a critical role in the development of colorectal cancer

作者：Bo Dong, Lie Yang, Bin Yang, Bin Zhou, Ben Niu, Taiqi Wang, Zhaowan Xu, Lin Zhu, Guang Hu, Wenjian Meng, Hong Zhang, Zong‐Guang Zhou, Xiao‐Feng Sun · 发表于：Chinese Medical Journal · 年份：2025 · DOI：10.1097/cm9.0000000000003860 · 被引用次数：1 · 研究领域：Peroxisome Proliferator-Activated Receptors、Kruppel-like factors research、Cancer, Lipids, and Metabolism

To the Editor: The role of the peroxisome proliferator-activated receptor (PPAR)δ in colorectal cancer (CRC) is controversial. Indeed, PPARβ/δ can inhibit cancer by inhibiting metastasis and promote cancer by promoting metastasis and angiogenesis.[1,2] The PPARδ-87T/C (also referred to as +294 T/C [rs2016520]) single-nucleotide polymorphism (SNP) is associated with the binding ability of the transcription factor specificity protein-1 (Sp-1).[3,4] Sp-1 is an important transcription factor in CRC tumorigenesis and progression.[5] Therefore, Sp-1 is a potential molecular marker of CRC progression and a promising therapeutic target in this malignancy. The purpose of this study was to investigate the impact of PPARδ-87T/C on transcription factor binding. This study assessed the relationship between the PPARδ-87T/C polymorphism, CRC risk, and key clinicopathological parameters in a Western Chinese Han population. This case-control study was approved by the Institutional Review Board of the West China Hospital (29-11-2021/No. 1308) and was registered (#ChiCTR2100054751, www.chictr.org.cn) on December 28, 2021. Written informed consent was obtained from the participants. Peripheral blood samples were collected from 410 patients with primary CRC and 496 controls. Genomic DNA was extracted for genotyping PPARδ-87T/C. The PPARδ-87T/C polymorphism nucleotide sequences were used to predict the differences in binding transcription factors of this SNP [Figure 1A and B]. Gene Ontology (GO) f...