A Clinical Tool to Identify Incidental Meningioma for Early Outpatient Management

作者：Abdurrahman I. Islim, Christopher P. Millward, Rasheed Zakaria, Rory J. Piper, Daniel M. Fountain, Shaveta Mehta, Ruwanthi Kolamunnage‐Dona, Usama Ali, Shelli D Koszdin, Theo Georgious, Ryan Mathew, Samantha J. Mills, Andrew Brodbelt, Thomas Santarius, Michael D. Jenkinson, Daniel M. Fountain, M. Poon, Angelos G. Kolias, Julie Woodfield, Rory J. Piper, Ajai Chari, Abdurrahman I. Islim, Neeraj Kalra, Michael McDermott, Thomas Santarius, Warren R. Selman, Marta Couce, Andrew E. Sloan, Bruno Carvalho, Patrick Y. Wen, Kyle M. Walsh, Eelke M. Bos, Wenya Linda Bi, Raymond Y. Huang, Priscilla K. Brastianos, Helen A. Shih, Tobias Walbert, Ian Lee, Michelle M. Felicella, Ana Valéria Castro, Houtan Noushmehr, James M. Snyder, Francesco DiMeco, Andrea Saladino, Bianca Pollo, Christian Schichor, Jörg‐Christian Tonn, Felix Ehret, Timothy J. Kaufmann, Daniel H. Lachance, Caterina Giannini, Evanthia Galanis, Aditya Raghunathan, Michael A. Vogelbaum, Jill S. Barnholtz‐Sloan, Patrick J. Cimino, Craig Horbinski, Mark W. Youngblood, Matija Snuderl, Sylvia C. Kurz, Erik P. Sulman, Ian F. Dunn, C. Oliver Hanemann, Mohsen Javadpour, Ho‐Keung Ng, Paul C. Boutros, Richard G. Everson, Alkiviadis Tzannis, Konstantinos Fountas, Nils Ole Schmidt, Karolyn Au, Roland Goldbrunner, Norbert Galldiks, Marco Timmer, Tiit Mathiesen, Manfred Westphal, Katrin Lamszus, Franz Ricklefs, Christel Herold‐Mende, Felix Sahm, Christine Jungk, Gerhard Jungwirth, Andreas von Deimling, Maximilian Deng, Susan Short, Michael D. Jenkinson, Christian Mawrin, Omar Pathmanaban, Katharine J. Drummond, Andrew Morokoff, David R. Raleigh, Arie Perry, Nicholas Butowski, Tathiane M. Malta, Viktor Zherebitskiy, Luke Hnenny, Gabriel Zada, Mirjam Renovanz, Antonio Santacroce, Christian la Fougère, Jens Schittenhelm, Peter Paßlack, Jennifer Moliterno, Alper Dincer, Debraj Mukherjee, Adham M. Khalafallah, Sachiv Chakravarti, Adrian E. Jimenez, Jiaqi Liu, Vivia Lung, Clarissa Alfonso, Keiko Fox, Sophie Liu, Mohamed Elsharif, Hanan Akbari, Esther Wu, Katharine J. Drummond, Verena Schadewaldt, Ryan Leyden, Andreas Fahlström, Benjamin Price, Francesco Gaillard, Rusiru T. Ekanayaka, Andranik Kahramanian, Amit Persad, E Liu, Luke Hnenny, Omar Elmandouh, Martin Proescholdt, Tobias Mederer, Sebastian Schachinger, Michael Amoo, Jack Henry, Pierfrancesco Lapolla, Placido Bruzzaniti, Pietro Familiari, Antonio Santoro, Andrea Mingoli, Giuseppa Zancana, Antony Kevin Scafa, Alessia D'Amico, Lora-Kay Darmanin, Richard Pullicino, Bente Sandvei Skeie, Torbjørn Austveg Strømsnes, Ferran Brugada-Bellsolà, P. Teixidor Rodríguez, Cristina Hostalot-Panisello, Roser García‐Armengol, Carlos Javier Domínguez-Alonso, Javier Martín-Alonso, Pedro David Delgado‐López, Hytham K. S. Hamid, Fawaz E. Marhoom, M. A. -R. Arbab, Asgeir Store Jakola, Olivia Näslund, Gildas Patet, Torstein R. Meling, Amir H. Zamanipoor Najafabadi, Fleur L. Fisher, Shamayitri Ghosh, Y H Chan, Giles Critchley, Omar Pathmanaban, Ruth Cairns, Emeka Samuel Nwokeocha, M. Ammar, Abed Alfattah Mahmoud Alnsour, Adnan Raed Alnaser, Josephine Jung, Maria Alexandra Velicu, Deva S. Jeyaretna, Arousa Ali, Bryony Ford, Isaac Phang, Omar Mohammed Yaseen, Zoubeyr Abbou Abbou, Belal A. Mohamed, Mohamed Okasha, Mustafa El Sheikh, L Alakandy, Kareem Austin, Elliot Tilling, Alexander Smedley, Ismail Ughratdar, Zenab Sher, Yasir A Chowdhury, Robert Bryce, Imran Noorani, Sara Venturini, Agbolahan Sofela, Sarah Kingdon, Anil Varma, Oliver Kennion, Jing Xian Lee, Harry Carr, Jonathan Pollock, Jarnail Bal, David Rowland, Hani J. Marcus, Andrew Gvozdanovic, Erminia Albanese, Bobby Sachdev, Aimee Goel, Daisy Evans, Anna Butcher, M. Mohammad, Melissa Gough, Damian Holliman, Philip V. Theodosopoulos, Jacob S. Young, Minh Phương Nguyễn, Stephen T. Magill, Ramin A. Morshed · 发表于：JAMA Oncology · 年份：2025 · DOI：10.1001/jamaoncol.2025.4821 · 被引用次数：3 · 研究领域：Meningioma and schwannoma management、Head and Neck Surgical Oncology、Brain Metastases and Treatment

Importance: Incidental meningiomas are common. There is a need for a validated clinical tool to stratify patients into early intervention, serial monitoring, or safe discharge from outpatient care. Objective: To externally validate the Incidental Meningioma: Prognostic Analysis Using Patient Comorbidity and Magnetic Resonance Imaging Tests (IMPACT) tool. Design, Setting, and Participants: This retrospective cohort study included 33 centers in 15 countries. Adult patients diagnosed with an incidental meningioma from January 2009 to December 2010 were included, up to the point of intervention, death, or last clinical encounter. Patients with radiation-induced meningioma and NF2-related schwannomatosis were excluded. Data collection was completed on December 31, 2023. Statistical analysis was conducted between March 2024 and December 2024. Main Outcomes and Measures: The primary outcome of the study was a composite end point comprising growth, symptom development, meningioma-related mortality, and end points related to loss of window of curability. Secondary end points included the occurrence of an intervention and nonmeningioma-related mortality. Results: Overall, 1248 patients were included. The median (IQR) age was 66 (55-77) years and 999 were female individuals (80%). There were 945 patients (75.7%) who had 1010 treatment-naive meningiomas. During follow-up (median [IQR], 61 [17-108] months), 114 tumors (11.3%) in 113 patients (12%) progressed, 132 tumors (13.1%) in 126 pat...