Comparative Evaluation of Responsiveness of Insulin Counter-Regulatory Hormones and Insulin Resistance to Hypoglycemia in Newly Diagnosed Type 1 Diabetes Mellitus Man

作者：Yunting Zhou, Junming Zhou, Jianhua Ma, Rengna Yan, Lu Yuan, Rong Huang, Yun Shen, Bo Ding · 发表于：Diabetes Metabolic Syndrome and Obesity · 年份：2025 · DOI：10.2147/dmso.s554306 · 被引用次数：1 · 研究领域：Diabetes Management and Research、Diabetes and associated disorders、Diabetes Treatment and Management

Aim: The mechanisms governing dynamic regulation of counterregulatory hormones in type 1 diabetes (T1DM) remain incompletely understood. To eliminate potential confounding effects of female sex hormones and menstrual cycle variations on insulin sensitivity and counter-regulatory hormone secretion, this study investigated the correlation between counter-regulatory hormone levels and insulin resistance in male patients with T1DM. Research Design and Methods: From March 2022 to December 2022, 34 male patients with newly diagnosed T1DM and 8 male normal people without DM were included. Counter-regulatory hormone levels and clinical characteristics were collected. All the included T1DM subjects were treated with intensive insulin therapy by insulin pump for 1 week to achieve glycemic control, followed by using the hyperinsulinemic-hypoglycemic clamp to determine the steady-state glucose infusion rate, an indicator of insulin sensitivity. The chemiluminescent immunometric assay was also used to measure circulating counter-regulatory hormones, such as glucagon (GCG), insulin-like growth factor-1 (IGF-1), adrenocorticotropic hormone (ACTH), growth hormone (GH), and cortisol (Cor) at 0min and 30min during hyperinsulinemic-hypoglycemic test. Correlation analysis was conducted to investigate the relationship between insulin-stimulated glucose disposal rates (M value) and counter-regulatory hormone levels. Results: The T1DM group exhibited lower fasting C-peptide levels than the normal g...