Predictors of damage accrual by organ domain in systemic lupus erythematosus

作者：Rangi Kandane‐Rathnayake, Luigi Zolio, Jiyoon Choi, Vera Golder, Worawit Louthrenoo, Yi‐Hsing Chen, Jiacai Cho, Aisha Lateef, Laniyati Hamijoyo, Shue‐Fen Luo, Yeong‐Jian Jan Wu, Sandra Navarra, Leonid Zamora, Zhanguo Li, Sargunan Sockalingam, Yasuhiro Katsumata, Masayoshi Harigai, Yanjie Hao, Zhuoli Zhang, Madelynn Chan, Jun Kikuchi, Tsutomu Takeuchi, Shereen Oon, Sang‐Cheol Bae, Fiona Goldblatt, Sean O’Neill, Kristine Ng, Annie Law, BMDB Basnayake, Nicola Tugnet, Sunil Kumar, Cherica Tee, Michael Tee, Yoshiya Tanaka, Chak Sing Lau, Alberta Hoi, Mandana Nikpour, Eric F. Morand · 发表于：Lara D. Veeken · 年份：2025 · DOI：10.1093/rheumatology/keaf610 · 被引用次数：2 · 研究领域：Systemic Lupus Erythematosus Research、Rheumatoid Arthritis Research and Therapies、Multiple Sclerosis Research Studies

OBJECTIVES: Organ damage in SLE is assessed using the SLICC/ACR Damage Index (SDI), which quantifies damage in 12 organ systems but generally reports a total score. We examined whether the risk factors for overall organ damage accrual captured those associated with domain-specific damage accrual in patients with SLE. METHODS: Data from a 13-country longitudinal SLE cohort were collected between 2013 and 2020 using standard templates. SDI was used to assess overall and domain-specific organ damage. A series of multi-failure, multivariate models were performed to examine the risk factors associated with overall and domain-specific damage accrual. RESULTS: A total of 3449 patients with a median of 2.8 [interquartile range (IQR): 1.1, 5.6] years of follow-up were studied. Twenty-one percent (n = 717) patients accrued damage in at least one domain during the study period (musculoskeletal, 6%; renal and ocular, 5% each, neuropsychiatric, 2.5%; <2%, other domains). Risk factors for damage accrual differed among domains. Older age, cumulative glucocorticoid dose, existing skin damage, and diabetes were strong predictors in multiple but discrete domains. Asian ethnicity conferred greater risk of ocular, musculoskeletal, and diabetic damage accrual but was protective against peripheral vascular damage accrual. Smoking was a significant risk factor for peripheral vascular and skin damage accrual, while male sex was associated with the malignancy domain. CONCLUSION: Risk factors for indi...