[Analysis on clinical features and risk factors for mortality in children with very early-onset inflammatory bowel dsease].

作者：Z Y Li, Jianying Zhang, Zihan Yu, Fei Xue, Y S Wang · 发表于：PubMed · 年份：2025 · DOI：10.3760/cma.j.cn112137-20250624-01536 · 研究领域：Medicine、Internal medicine、Gastroenterology、Surgery

The children with VEO-IBD who died of VEO-IBD exhibited a state of hyperinflammation. Single gene mutation (IL-10RA、IL-10RB、CYBB、DOCK8、BTK、TNFAIP3、ELANE、WASP), age<7.5 months, severe malnutrition, and a history of critical surgical intervention are risk factors for mortality in children with VEO-IBD.