Visible-Light-Driven C(sp 3 )–H Bond Carboxylation of Benzyl Amines with CO 2 for the Synthesis of α-Amino Acids

作者：Wenwen Cui, Bin Li, Baiquan Wang · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c04040 · 被引用次数：9 · 研究领域：Carbon dioxide utilization in catalysis、Radical Photochemical Reactions、CO2 Reduction Techniques and Catalysts

α-Amino acids are vital structural motifs in both bioactive compounds and synthetic building blocks. However, the photocatalytic synthesis of α-amino acids directly from C(sp 3 )–H bonds and CO 2 is a long-standing challenge. Here we report a visible-light-driven C(sp 3 )–H bond carboxylation of benzylamine with CO 2 to synthesize substituted arylglycines. This reaction has mild reaction conditions, good functional group tolerance, and a wide substrate scope. Mechanistic studies show that carbon radicals and carbon anions as the key intermediates may be generated through a consecutive photoinduced electron transfer process.