MIND diet adherence and cognitive function in Alzheimer's disease: Mediating roles of neural oscillatory markers from resting‐state EEG

作者：Shijing Wu, Lihua Chen, Yurou He, Juanli Liu, Zhangjing Deng, Yingxi Chen, Zehu Sheng, Boyuan Xia, Ying Tan, Siyu Pan, Nan Lu, Weihua Yu, Yang Lü · 发表于：Psychiatry and Clinical Neurosciences · 年份：2025 · DOI：10.1111/pcn.13923 · 被引用次数：1 · 研究领域：Nutritional Studies and Diet、Diet and metabolism studies、Dementia and Cognitive Impairment Research

AIM: Adherence to the Mediterranean-dietary approaches to stop hypertension (DASH) intervention for neurodegenerative delay (MIND) diet has been associated with a reduced risk of dementia, yet clinical and mechanistic evidence is limited. This study aims to explore the relationship between MIND diet adherence and cognitive function in Alzheimer's disease (AD), with a specific focus on resting-state EEG to investigate the underlying mechanisms. METHODS: We evaluated 841 memory clinic participants: 119 cognitively normal, 255 with mild cognitive impairment, and 467 with AD. Cognitive, dietary, neuropsychiatric, and functional data were collected. EEG from 204 participants was analyzed for spectral and connectivity features. RESULTS: MIND scores were significantly lower in the AD group (P < 0.001). Higher MIND adherence was linked to better global cognition, lower dementia severity, fewer mood symptoms, and greater daily functioning (P < 0.05). Individuals in the lowest adherence tertile had 6.78 times higher odds of cognitive impairment compared to those in the highest tertile (OR = 6.78, 95% CI: 4.54-10.13, P < 0.001). EEG analyses revealed that greater MIND adherence was associated with increased alpha power, reduced occipital theta/beta and delta/alpha ratios, and stronger frontoparietal connectivity. Mediation analysis indicated that frontal and global alpha power partially mediated the associations between MIND diet adherence and dementia severity, mood symptoms, and funct...