Associations of the geriatric nutritional risk index and simplified geriatric nutritional risk index with chronic obstructive pulmonary disease

作者：Yiben Huang, Rui‐Hua Xu, Xuanyang Chen, Siyao Chen, Zicong Dai, Xinran Li, Yiting Yu, Zihan Ye, Xianjing Chen, Chunyan Liu, Beibei Yu, Yage Xu, Xiaodiao Zhang · 发表于：Chronic Respiratory Disease · 年份：2025 · DOI：10.1177/14799731251400261 · 被引用次数：1 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Nutrition and Health in Aging、Nutritional Studies and Diet

Purpose This study aimed to investigate the associations of the Geriatric Nutritional Risk Index (GNRI) and the simplified Geriatric Nutritional Risk Index (sGNRI) with Chronic Obstructive Pulmonary Disease (COPD). Methods We assessed 161 patients with COPD and 947 healthy controls. The sGNRI was derived using the formula: serum albumin (g/dL) + 0.1 × body mass index (BMI, kg/m 2 ). Primary outcomes included the BODE (body mass index, airflow obstruction, dyspnea, exercise capacity) index and hospital length of stay (LOS). The secondary outcome was the prevalence of COPD. Results Malnourished patients (GNRI <95.40 or sGNRI <5.89) exhibited lower BMI and albumin levels, as well as worse pulmonary function (all p < 0.05). GNRI (Odds Ratio [OR] = 0.945, 95% Confidence Interval [CI]: 0.903-0.989, p = 0.015) and sGNRI (OR = 0.413, 95% CI: 0.191-0.890, p = 0.024) were significantly associated with the severity of COPD in a multivariable-adjusted model. Subgroup analysis revealed stronger predictive performance of GNRI and sGNRI among males, non-hypertensive patients, and smokers (for sGNRI). Conclusions Compared with GNRI, sGNRI may serve as a more practical tool for identifying malnutrition-related risk among patients with COPD.