CT-Based Radiomics-Clinical Model for Predicting Recurrence in VETC-Positive HCC Patients After Hepatectomy

作者：Yu Lei, Yaowei Bai, Su Yang, Xiatong Bai, Yingliang Wang, Chuansheng Zheng · 发表于：Journal of Hepatocellular Carcinoma · 年份：2025 · DOI：10.2147/jhc.s549825 · 被引用次数：1 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、Radiomics and Machine Learning in Medical Imaging、Cholangiocarcinoma and Gallbladder Cancer Studies

Objective: To construct a radiomics-based model for predicting postoperative recurrence in hepatocellular carcinoma (HCC) patients with vessels encapsulating tumor clusters (VETC) positive based on CT scan. Methods: This retrospective study enrolled patients who underwent surgical resection between January 2016 and January 2024 at Union Hospital, with pathologic confirmation of HCC and VETC status. An external test set was drawn from Chegu Hospital, covering January 2018 to January 2022. Tumor segmentation was performed on portal venous phase CT scan, and then radiomics features were extracted. These features were further analyzed using the LASSO algorithm and combined with clinical features to construct a radiomics-clinical combination model. Model performance was evaluated using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA). Patients were divided into high- and low-risk groups based on model scores, and Kaplan-Meier (KM) curves were compared. Results: A total of 243 patients were included (median age 56.7 years, 211 males). Nine radiomics features and two clinical features were selected to construct the combined model. The area under the ROC curve (AUC) for predicting 1-year recurrence was 0.898 (95% CI: 0.797-0.999) in the internal test set and 0.804 (95% CI: 0.641-0.967) in the external test set. Calibration curves and DCA demonstrated high net clinical benefit of the combined model. The median recurrence-free surviv...