Digital twins in healthcare: a comprehensive review and future directions

作者：Hamid Khoshfekr Rudsari, Becky Tseng, Hongxu Zhu, Lulu Song, Chunhui Gu, Abhishikta Roy, Ehsan Irajizad, Joseph D. Butner, James P. Long, Kim‐Anh Do · 发表于：Frontiers in Digital Health · 年份：2025 · DOI：10.3389/fdgth.2025.1633539 · 被引用次数：44 · 研究领域：Artificial Intelligence in Healthcare and Education、Digital Transformation in Industry、3D Printing in Biomedical Research

Digital Twin (DT) technology has emerged as a transformative force in healthcare, offering unprecedented opportunities for personalized medicine, treatment optimization, and disease prevention. This comprehensive review examines the current state of DTs in healthcare, analyzing their implementation across different physiological levels-from cellular to whole-body systems. We systematically review the latest developments, methodologies, and applications while identifying challenges and opportunities. Our analysis encompasses technical frameworks for cardiovascular, neurological, respiratory, metabolic, hepatic, oncological, and cellular DTs, highlighting significant achievements such as population-scale cardiac modeling (3,461 patient cohort), reduced atrial fibrillation recurrence rates through patient-specific cardiac models, improved brain tumor radiotherapy planning, advanced liver regeneration modeling with real-time simulation capabilities, and enhanced glucose management in diabetes. We detail the methodological foundations supporting different DT implementations, including data acquisition strategies, physics-based modeling approaches, statistical learning algorithms, neural network-based control systems, and emerging artificial intelligence techniques. While discussing implementation challenges related to data quality, computational constraints, and validation requirements, we provide a forward-looking perspective on future opportunities for enhanced personalization, ...