Adult myopia progression in high myopes aged 18–25 years: evidence from a population-based cohort

作者：Haotian Wu, Zhenhong Ni, Ziyi Qi, Tianyu Cheng, Tianwei Qian, Lingyi Zhao, Yanjiao Wang, Jinliuxing Yang, Jingjing Wang, Bo Zhang, Xun Xu, Xiangui He · 发表于：British Journal of Ophthalmology · 年份：2025 · DOI：10.1136/bjo-2025-328046 · 被引用次数：4 · 研究领域：Ophthalmology and Visual Impairment Studies、Corneal surgery and disorders、Scoliosis diagnosis and treatment

AIMS: To investigate the prevalence and severity of adult myopia progression among highly myopic individuals aged 18-25 years, identify its associated factors and evaluate its association with pathologic myopia (PM). METHODS: We retrospectively included participants aged 18-25 years with consecutive follow-ups from the Shanghai Child and Adolescent Large-scale Eye Study database. Annual changes of cycloplegic spherical equivalent (ΔSE) and axial length (ΔAL) were calculated. Adult myopia progression is defined as ΔSE ≤-0.50 D/year or ΔAL≥0.10 mm/year. PM was diagnosed based on META-Analysis for Pathologic Myopia criteria (category≥2) and optical coherence tomography (OCT) images. RESULTS: Among all included 345 eyes, the mean ΔSE was -0.28 D/year (95% CI -0.31 to -0.20; p<0.001) and 64 (18.6%) were classified as having adult myopia progression. The mean ΔAL was 0.09 mm/year (95% CI 0.09 to 0.10; p<0.001), with axial elongation observed in 138 (40.0%) eyes. Both age (ΔSE: β=0.045, p=0.005; ΔAL: β=-0.015, p<0.001) and baseline AL (ΔSE: β=-0.044, p=0.028; ΔAL: β=0.020, p<0.001) were identified as factors associated with ΔSE and ΔAL. No differences in ΔSE (95% CI -0.08 to 0.11; p=0.759) or ΔAL (95% CI -0.04 to 0.01; p=0.190) were found between PM and non-PM groups, and neither metric improved PM discrimination. CONCLUSIONS: Among high myopic individuals aged 18-25 years, 18.6% exhibited adult myopia progression and 40.0% showed axial elongation. Age and baseline AL were associate...