Clinical characteristics and mortality risk factors among hospitalized infants and children with pertussis in China: a retrospective study

作者：S. Zheng, Feng Luo, Ying Su, Xinyu Liu, Rongrong Dai, Xuan Deng, Yao Zhu, Yang Zhou, Hanqing He, Chunzhen Hua, Hangjie Zhang · 发表于：Frontiers in Public Health · 年份：2025 · DOI：10.3389/fpubh.2025.1663885 · 被引用次数：2 · 研究领域：Bacterial Infections and Vaccines、Pneumonia and Respiratory Infections、Immune responses and vaccinations

Background The resurgence of pertussis has emerged as a significant global public health threat. Severe pertussis primarily affects infants and children and is often associated with serious complications or death. Methods We retrospectively evaluated the clinical data of 197 hospitalized children with pertussis admitted to Children’s Hospital, Zhejiang University School of Medicine, from 2019 to 2024. Patients were categorized into severe and mild cases groups based on their admission ward. Multivariate logistic model was applied to explore associated factors. Results Among the 197 hospitalized children, those born prematurely or younger than 3 months were more likely to be admitted to the pediatric intensive care unit (PICU). All patients admitted to the PICU were infants who were either unvaccinated or incompletely vaccinated against pertussis. The most common clinical symptoms among hospitalized children were pneumonia, paroxysmal cough, and flushing. The severe cases group exhibited significantly higher levels than the mild cases group in length of stay, duration of antibiotic treatment, white blood cell (WBC) count, pneumonia, respiratory failure, and tachypnea ( p < 0.05). Multivariate logistic regression analysis identified cefuroxime usage [odds ratio (OR) = 0.10, 95% confidence interval (CI) = 0.01–0.92], high WBC count (OR = 0.79, 95% CI = 0.69–0.91), and high neutrophil percentage (OR = 1.49, 95% CI = 1.22–1.82) as independent risk factors for PICU admission...