Comparing Palliative Approaches for GOO in Locally Advanced Pancreatic Cancer: A Systematic Review and Meta‐Analysis

作者：Asad Gul Rao, Muhammad Nadeem, Abdul Rafeh Awan, Chase J. Wehrle, Abby Gross, Antonio Giuseppucci, Beren Berber, Syed Mohiuddin, Tyler Stevens, Hassan Siddiki, Kathryn A. Stackhouse, Samer A. Naffouje, David E. Joyce, Toms Augustin, Robert L. Simon, R. Matthew Walsh, Rob Naples · 发表于：Journal of Surgical Oncology · 年份：2025 · DOI：10.1002/jso.70131 · 被引用次数：2 · 研究领域：Esophageal and GI Pathology、Pancreatic and Hepatic Oncology Research、Gallbladder and Bile Duct Disorders

Gastric outlet obstruction (GOO) in locally advanced pancreatic cancer (LAPC) can be managed with endoscopic duodenal stenting (EDS), gastrojejunostomy (GJ), or EUS-guided gastroenterostomy (EUS-GE). In our meta-analysis of LAPC patients, EDS enabled quicker recovery and chemotherapy but had higher re-intervention rates, while GJ offered greater durability. Our systematic review showed EUS-GE had high success and low re-intervention in malignant GOO, though LAPC-specific data were lacking. Further comparative studies are needed to guide individualized treatment.