The relationship between cholesterol, high-density lipoprotein, and glucose index and hypertension: A study based on two national cohorts

作者：Zhe Zhang, Shushen Weng, Dong Cai, Lingling Zhao, Mengting Chen · 发表于：Science Progress · 年份：2025 · DOI：10.1177/00368504251396781 · 被引用次数：10 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Lipoproteins and Cardiovascular Health、Blood Pressure and Hypertension Studies

BackgroundHypertension remains a major global public health concern and is strongly linked to metabolic dysregulation. The cholesterol-high-density lipoprotein-glucose index, a recently proposed composite marker that integrates lipid and glycemic parameters, has not been comprehensively investigated in relation to hypertension.MethodsData from two nationally representative cohorts were analyzed: the China Health and Retirement Longitudinal Study (CHARLS) for longitudinal evaluation and the US National Health and Nutrition Examination Survey (NHANES) for cross-sectional assessment. Logistic regression analyses were used to examine the association between the cholesterol-high-density lipoprotein-glucose index and hypertension. Restricted cubic spline models were applied to assess potential non-linear relationships, while receiver operating characteristic curves were employed to evaluate the discriminative capacity of the cholesterol-high-density lipoprotein-glucose index. Sensitivity analyses were conducted to confirm the robustness of the findings.ResultsA total of 4031 participants from CHARLS and 10,355 participants from NHANES were included. Higher cholesterol-high-density lipoprotein-glucose index values were significantly and independently associated with an increased risk of hypertension in both cohorts. In the CHARLS cohort, each one-unit increase in cholesterol-high-density lipoprotein-glucose corresponded to a 1.60-fold higher risk of hypertension after full adjustmen...