Anxiety and depression and secondary prevention of coronary heart disease in 14 countries across six WHO regions: the INTERASPIRE study

作者：Chantal F. Ski, Catriona Jennings, Dirk De Bacquer, Kornelia Kotseva, John W. McEvoy, Guy De Backer, Iris Erlund, Sandra Ganly, Terhi Vihervaara, Gregory Y.H. Lip, Kausik K. Ray, Lars Rydén, Agnieszka Adamska, Ana Abreu, Wael Almahmeed, Ade Meidian Ambari, Junbo Ge, Hosam Hasan‐Ali, Yong Huo, Piotr Jankowski, Rodney M Jimenez, Yongbo Li, Ahmad Syadi Mahmood Zuhdi, Abel Makubi, Amam Mbakwem, Lilian Mbau, José L. Estrada, Okechukwu S. Ogah, Elijah Ogola, Adalberto Quintero-Baiz, MahmoudUmar Sani, María Inés Sosa Liprandi, Jack Wei Chieh Tan, Miguel Urina‐Triana, Tee Joo Yeo, David Wood, David R. Thompson · 发表于：European Journal of Preventive Cardiology · 年份：2025 · DOI：10.1093/eurjpc/zwaf725 · 被引用次数：6 · 研究领域：Cardiac Health and Mental Health、Cardiovascular Health and Risk Factors、Diabetes Management and Education

Abstract Aims Anxiety and depression are associated with poor outcomes in patients with coronary heart disease (CHD), however their association with achieving recommended cardiovascular prevention standards is unclear. We examined this association across all World Health Organization (WHO) regions. Methods and results Cross-sectional analysis of the INTERASPIRE study of adults hospitalized in the preceding 6–24 months with incident or recurrent CHD who underwent a standardized interview and examination (2020–2023) across 14 countries. The main outcome was the INTERASPIRE-Guideline Target Score (GTS); a 10-point assessment of achieving secondary prevention lifestyle, risk factor, and therapeutic targets. A total of 4546 patients (21.1% women) with a mean (SD) age of 60.0 (10.3) were interviewed. Prevalence’s of anxiety and/or depression were greater in women than men, and prevalence of CHD lifestyle and behavioral risk factors increased alongside severity of anxiety and depression symptoms. Compared to those without symptoms, adjusted odds ratios for achieving a suboptimal INTERASPIRE-GTS were: 1.52 (95% CI 1.13–2.04, P = 0.006) for symptoms of depression; 1.57 (95% CI 1.09–2.26, P = 0.015) for “possible” comorbid anxiety and depression; and 2.09 (95% CI 1.22–3.57, P = 0.007) for those with “probable” comorbid anxiety and depression. Conclusion Increasing severity of depression and anxiety symptoms are associated with reduced potential for achieving guideline standards for CHD...