Unhealthy diet quality as a clinical phenotype in bipolar disorder: A potential treatment target for improved mood and metabolic outcomes

作者：Manuel Gardea‐Resendez, Vanessa Pazdernik, Sofia Jezzini-Martinez, Brandon J. Coombes, Lindsay M Melhuish Beaupre, Ada Man‐Choi Ho, Jorge A. Sánchez-Ruiz, Alessandro Miola, Mete Ercis, Ana C. Andreazza, Balwinder Singh, Ayşegül Özerdem, Susan L. McElroy, Joanna M. Biernacka, Mark A. Frye, Alfredo B. Cuéllar‐Barboza, Francisco Romo‐Nava · 发表于：Journal of Affective Disorders · 年份：2025 · DOI：10.1016/j.jad.2025.120632 · 被引用次数：2 · 研究领域：Bipolar Disorder and Treatment、Nutritional Studies and Diet、Diet and metabolism studies

OBJECTIVES: This study aimed to investigate unhealthy diet quality in bipolar disorder (BD) and its association with social, metabolic and clinical features in a cohort of well-characterized adult patients with BD. METHODS: This study analyzed a subset of 737 adult participants from the Mayo Clinic Bipolar Disorder Biobank (MCBB) who completed the Rapid Eating Assessment for Participants - Shortened Version (REAP-S) diet quality questionnaire, in which scores <32 indicate an unhealthy diet quality (UDQ). Demographic and clinical variables were compared between individuals with unhealthy and healthy diet quality. Regression models were constructed to explore associations between UDQ and demographic variables, bipolar subtype, chronotype, medical comorbidities, psychotropics and differences in social determinants of health-related stressors. RESULTS: Individuals with BD and UDQ (78.8 %) were significantly younger, more likely to be male, and to have a diagnosis of BD-I or schizoaffective bipolar subtype. Additionally, UDQ was significantly associated with evening chronotype, binge eating disorder, comorbid anxiety disorders, obesity, hypertension, and unemployment-related stress. A multivariable logistic regression model identified that a higher education level and older age at BD diagnosis were associated with lower odds of UDQ, while an evening chronotype and comorbid anxiety disorders increased the likelihood of UDQ. LIMITATIONS: The study design limits causality assessment ...