Automatic dual‐modality breast tumor segmentation in PET/CT images using CT‐guided transformer

作者：Huizhong Zheng, Dan Shao, Zhenxing Huang, Yongfeng Yang, Hairong Zheng, Dong Liang, Yuan Yao, Xiangjian He, Zhanli Hu · 发表于：Medical Physics · 年份：2025 · DOI：10.1002/mp.70136 · 被引用次数：2 · 研究领域：Medical Imaging Techniques and Applications、Radiomics and Machine Learning in Medical Imaging、Digital Radiography and Breast Imaging

BACKGROUND: Breast tumor segmentation is crucial for the diagnosis of breast cancer, as it enables radiologists to rapidly identify areas of interest and facilitate subsequent analysis, diagnosis, and treatment. Present breast tumor segmentation methods are typically applied to high-resolution computed tomography images. However, fewer segmentation methods are utilized for positron emission tomography/computed tomography (PET/CT) imaging systems. PURPOSE: Our goal is to develop a deep learning algorithm which combines functional and structural information for breast tumor segmentation in PET/CT images. This can enhance analytical accuracy and speed up the process of obtaining segmentation outcomes, thereby assisting physicians in subsequent patient diagnosis and treatment. METHODS: In this study, we explore an automatic image segmentation model to segment breast tumors in PET images. The proposed CT-Guided Transformer modules utilize features of various scales from CT images to generate attention maps for PET features. During the fusion process, effective consensus information is extracted from the features of two different modalities using similarity-based contrastive learning, thus enhancing the segmentation performance. Five evaluation metrics (Jaccard coefficient, Dice score, precision, sensitivity, and Hausdorff distance) are utilized to evaluate segmentation performance. The proposed algorithm is compared to the single-modality method and other multimodal fusion strateg...