Global, regional, and National burden of falls among midlife women from 1990 to 2021 and projections to 2050: A systematic analysis for the global burden of disease study 2021

作者：Lang Wang, Yushuai Mi, Xianglin Zhu, Ziping Liu, Junjian Liu, Cheng Zhao, Shijun Zhao, Hao Liang, Jie Zhang, Tian Gao, Yinlu Ding · 发表于：Aging Clinical and Experimental Research · 年份：2025 · DOI：10.1007/s40520-025-03210-5 · 被引用次数：6 · 研究领域：Menopause: Health Impacts and Treatments、Balance, Gait, and Falls Prevention、Bone health and osteoporosis research

BACKGROUND: Declining estrogen in perimenopausal women reduces bone mineral density and increases bone fragility, elevating fall and fracture risk. This presents major challenges for patients and society, yet prior studies lack systematic analysis of this population. This study is the first to utilize mortality and disability-adjusted life years (DALYs) related to falls among perimenopausal women from the Global Burden of Disease (GBD) 2021 database, and to conduct a comprehensive and systematic analysis of the evolving burden of falls in perimenopausal women from 1990 to 2021, as well as to project trends through 2050. This study offers key guidance for optimizing healthcare resource allocation, enhancing patient management, and developing targeted prevention and intervention strategies. METHODS: This study used GBD 2021 data to systematically analyze fall-related mortality, DALYs, age-standardized rates (ASRs), and estimated annual percentage change (EAPC) among perimenopausal women, examining their associations with the Socio-demographic Index (SDI) at global, regional, and national levels. Joinpoint regression, decomposition, health inequality, and frontier analyses quantified trends, identified factors, and assessed disparities. This study also explored fall risk factors and utilized the Bayesian Age-Period-Cohort (BAPC) model to project global trends in fall burden among perimenopausal women from 2022 to 2050. RESULTS: Between 1990 and 2021, global mortality attributabl...