Early-Onset of Obesity Model: Impact of Early-Onset Obesity on Comorbidity Risk and Life Expectancy

作者：Urs Wiedemann, Erica L T van den Akker, Thomas M. Barber, Karine Clément, I. Sadaf Farooqi, Anthony P. Goldstone, Andrea M. Haqq, Claude Marcus, Dénes Molnár, Luís A. Moreno, Evan P. Nadler, Christine Poitou, Jan Luca Schorfheide, Nicolas Touchot, Martin Wabitsch, Peter Kühnen · 发表于：Obesity Facts · 年份：2025 · DOI：10.1159/000549499 · 被引用次数：3 · 研究领域：Birth, Development, and Health、Obesity, Physical Activity, Diet、Diabetes, Cardiovascular Risks, and Lipoproteins

Introduction: Early-onset obesity increases the risk of developing comorbidities and decreases life expectancy with many variables such as age of onset, severity, and duration of obesity each having an individual influence. Here, we present findings from a model that aims to assess the impact of early-onset obesity. METHODS: The Early-Onset Obesity Model (EOObesity Model) was built by integrating data from clinical studies with demographic information. It categorizes information into four primary groups: prevalence, morbidity risk, mortality risk, and impact of obesity duration. Type 2 diabetes, cardiovascular events (fatal and nonfatal events, cardiovascular disease, and coronary heart disease), metabolic dysfunction-associated steatotic liver disease, asthma, obstructive sleep apnea, and cancer were evaluated over a range of age and body mass index (BMI) z-scores. RESULTS: The EOObesity Model provides a systematic approach for estimating the impact of early-onset obesity on risk of comorbidities and on life expectancy by considering individual patient weight trajectories. We test different scenarios to illustrate the potential impact of age of onset and severity of obesity on the risk of various comorbidities, on life expectancy, and on disability-adjusted life years. The model indicates that severe early-onset obesity has a high impact on life expectancy with, for example, up to 42 years of life lost if a patient has a BMI z-score of 4 by the age of 4 years. DISCUSSION: Th...