Donepezil treatment, alone or combined with exercise, enhances skeletal muscle function in healthy and advanced aging disease mouse models

作者：Nicholas J. Ernst, Edziu Franczak, Julie Allen, Everett C. Minchew, Andrew T. Readyoff, Martin Farlow, Espen E. Spangenburg, Benjamin F. Miller, Jill K. Morris, Kartik Shankar, Mihaela E. Sardiu, Hao Zhu, John A. Stanford, John P. Thyfault, Colin S. McCoin · 发表于：Journal of Applied Physiology · 年份：2025 · DOI：10.1152/japplphysiol.00895.2024 · 被引用次数：1 · 研究领域：Cholinesterase and Neurodegenerative Diseases、Genetics, Aging, and Longevity in Model Organisms、Amyotrophic Lateral Sclerosis Research

Aging is often accompanied by a decline in muscle mass and function, with limited effective treatments. The study provides novel insights into the potential of donepezil, an acetylcholinesterase medication primarily used for dementia, to improve skeletal muscle health and function.