A personal perspective of patient-centred clinical trials

作者：Trevor Tyne, Elizabeth Ivimey, Leanne Duggan, Jia Liu · 发表于：Oncotarget · 年份：2025 · DOI：10.18632/oncotarget.28776 · 被引用次数：1 · 研究领域：Ethics in Clinical Research、Mental Health and Patient Involvement、Biomedical Ethics and Regulation

// Trevor Tyne 1 , * , Elizabeth Ivimey 1 , * , Leanne Duggan 1 , * and Jia Liu 1 , 2 , 3 1 The Kinghorn Cancer Centre, St Vincent’s Hospital, Sydney, NSW, Australia 2 School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia 3 Garvan Institute of Medical Research, Sydney, NSW, Australia * These authors contributed equally to this work Correspondence to: Jia Liu, email: jia.liu@svha.org.au Keywords: precision oncology; patient-centric care; clinical trials; tumor agnostic; drug development Received: October 13, 2025     Accepted: October 21, 2025     Published: November 14, 2025 Copyright: © 2025 Tyne et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Key objective: To illustrate the first-hand journey of three early phase trial participants highlighting their benefits and challenges of participation and patient-centric innovations required to improve trial experience. Knowledge generated: Early phase trials have traditionally centred on dose-finding and toxicity. However as they have increased in number and improved in therapeutic intent, the patient experience becomes increasingly important. This article illustrates benefits of participation including access to n...