All‐Hydrogel‐Based Organic Electrochemical Transistors for Implantable Physiological Signal Monitoring

作者：Qicheng Liang, Yue Wang, Ruizhe Wang, W. C. Zhang, Runcheng Hao, Yueheng Zhong, Jingling Zhang, Xiang Li, Weichu Chen, Chunyu Fan, Yuwen Zhu, Yu Sun, Hong Jiang, Hengda Sun, Gang Wang · 发表于：Advanced Science · 年份：2025 · DOI：10.1002/advs.202517375 · 被引用次数：7 · 研究领域：Conducting polymers and applications、Advanced Sensor and Energy Harvesting Materials、Organic Electronics and Photovoltaics

Organic electrochemical transistors (OECTs) are an advanced technology for interfacing with biology, capable of efficiently transducing ionic currents into amplified electronic signals at low operating voltages. However, their clinical potential is critically undermined by the mechanical mismatch between conventional device materials and soft tissues. This fundamental limitation is resolved by developing a versatile all-hydrogel-based OECT, which is made possible by a novel n-type depletion-mode semiconductor hydrogel. Fabricated via an ionic liquid-mediated phase separation of poly(benzodifurandione)/polyacrylamide, the material uniquely combines efficient ion-electron coupled transport with tissue-like softness. This fully compliant architecture delivers a high transconductance of 43 mS, remains stable over 1500 bending cycles, and shows excellent biocompatibility. The devices enable real-time monitoring of human electrocardiography/electrooculogram (ECG/EOG) signals on the skin and long-term subcutaneous recording of nociceptive/ECG signals in rats. This study provides a robust materials and device strategy, establishing a versatile platform for multimodal physiological signal monitoring, pain assessment, cardiovascular health evaluation, and implantable precision bioelectronic therapy.