MicroRNA‐Enriched Plant‐Derived Exosomes Alleviate Colitis by Modulating Systemic Immunity, Metabolic Homeostasis, and Gut Microbiota (Adv. Sci. 42/2025)

作者：Ruipeng Shi, Wen Tan, Haochun Jin, Sio I Chan, Wei Li, Si San Lei, Guozhen Cui, Yitao Wang, Dong‐Hua Yang, Zhangfeng Zhong · 发表于：Advanced Science · 年份：2025 · DOI：10.1002/advs.72372 · 被引用次数：8 · 研究领域：Extracellular vesicles in disease、Endoplasmic Reticulum Stress and Disease、Gut microbiota and health

Plant-Derived Exosomes Rooted in millennia-old herbal wisdom, plant-derived exosomes emerge as potent regulators of uncontrolled inflammatory cascades in colitis. Like turbulent crimson waters surging from the upstream Yarlung Tsangpo Dam, inflammation disrupts mucosal equilibrium. Yet, Nezha, depicted on lotus leaves, releases plant-derived exosomes enriched with miRNAs through a metaphorical conduit. This natural cross-kingdom dialogue transforms pathological chaos into physiological harmony, restoring immune balance, metabolic balance, and gut microbial symbiosis. More details can be found in the Research Article by Dong-Hua Yang, Zhangfeng Zhong, and co-workers (DOI: 10.1002/advs.202505921).