Illuminating the genomic frontier of invasive non‐typhoidal Salmonella infections

作者：Hao Wang, Li Tang, Haiyang Zhou, Peilu Xie, Min Yue · 发表于：Clinical and Translational Medicine · 年份：2025 · DOI：10.1002/ctm2.70526 · 被引用次数：4 · 研究领域：Salmonella and Campylobacter epidemiology、Listeria monocytogenes in Food Safety、Viral gastroenteritis research and epidemiology

In October 2024, the World Health Organisation (WHO) designated non-typhoidal serovars of Salmonella enterica as a global high-risk agent for Public Health Emergency of International Concern (PHEIC), spotlighting this urgent threat to global public health.1 Unlike non-invasive serovars, which typically cause gastroenteritis, the invasive non-typhoidal Salmonella (iNTS) ones drive severe extraintestinal infections, responsible for approximately 87,100 deaths annually, with mortality rates of 18.1%.3 The burden is critically compounded by the escalating crisis of antimicrobial resistance (AMR). While historically recognised as a major public health issue in Africa,4 often associated with HIV and malaria co-infections,5 its epidemiology and transmission dynamics in other regions remain poorly understood. To fill the gap, our group has reported several invasive non-typhodial Salmonella serovars (Goldcoast, Livingstone, Telelkebir and Uzaramo) circulating.6-9 Most recently, our large-scale genomic epidemiology study in China,10 combining whole-genome sequencing with advanced Bayesian analyses, has uncovered a disturbing evolutionary shift from serovar Choleraesuis to Enteritidis. Challenging the conventional understanding of iNTS as a zoonotic disease transmitted from animals, our genomic evidence, as well as the patient cohort, demonstrates that iNTS is adapting to humans and evolving toward sustained human-to-human transmission.10 Growing recognition of the bacterium's pandemic ...