Clinical epidemiological characteristics and treatment outcomes of Brucella spondylitis in Ningxia, China: a 12‑year single‑center retrospective study

作者：Kun Wang, Zhifeng Gu, Qiang Liu, Long Ma, Minyu Li, Hanhua Guo, Ju Gao, Zongqiang Yang, Jiandang Shi · 发表于：BMC Infectious Diseases · 年份：2025 · DOI：10.1186/s12879-025-12101-z · 被引用次数：6 · 研究领域：Brucella: diagnosis, epidemiology, treatment、Burkholderia infections and melioidosis、Infectious Disease Case Reports and Treatments

BACKGROUND: Epidemiological and clinical analyses of Brucellar spondylitis (BS) are crucial for public health authorities to enhance disease surveillance and optimize case management strategies. However, clinical epidemiological research on BS remains limited. This study analyzed the clinical and epidemiological characteristics of hospitalized BS patients at a hospital in Ningxia, aiming to provide evidence to support region-specific strategies for BS prevention and control. METHODS: We retrospectively collected demographic profiles, epidemiological characteristics, clinical presentations, laboratory/imaging findings, therapeutic regimens, and prognostic outcomes of BS inpatients admitted to the orthopedic department of a hospital in Ningxia from January 2012 to December 2023. RESULTS: A total of 821 patients with BS were included, consisting of 564 males (68.7%; 564/821) and 257 females (31.3%; 257/821), with a median age of 55 years (range: 18-88 years). Among all patients (n = 821), 466 (56.76%) were agricultural or pastoral workers, and 578 (70.4%) had a documented history of contact with cattle or sheep. Low back pain was the most common presenting symptom, reported in 779 cases (94.88%; 779/821). The combined positive rate of the Rose Bengal Plate Test (RBPT) and the Standard Agglutination Test (SAT) in serological testing was 90.99% (747/821). Blood cultures were performed in 618 patients, of whom 217 (35.11%; 217/618) yielded positive results. Imaging examinations rev...