Staged Reconstruction Is Not Necessary Following Oncologic Resection of Superficial Myxofibrosarcoma

作者：LEILANI GARAYUA-CRUZ, Samuel E. Broida, Mikaela H. Sullivan, Andrew L. Folpe, Meng Xu‐Welliver, K.N. Lee, Brittany L. Siontis, Steven I. Robinson, Thanh P. Ho, Scott H. Okuno, Peter S. Rose, Karim Bakri, Steven L. Moran, Matthew T. Houdek · 发表于：Cancers · 年份：2025 · DOI：10.3390/cancers17223637 · 被引用次数：1 · 研究领域：Sarcoma Diagnosis and Treatment、Bone Tumor Diagnosis and Treatments、Reconstructive Surgery and Microvascular Techniques

BACKGROUND: Myxofibrosarcomas are notoriously highly infiltrative soft-tissue sarcomas, making negative surgical margins difficult to obtain. Recently, vacuum-assisted closure (VAC) is used to delay wound closure until a negative margin has been achieved; however, this can delay care and increase costs. Our institution has historically performed single-stage resections with intraoperative frozen margin analysis and reconstruction in these patients. The purpose of this study is to report the outcomes of this technique. METHODS: We reviewed 112 patients (62 males, mean age 70 ± 14 years) with superficial myxofibrosarcoma. Eighty-eight patients received preoperative radiation. All patients underwent surgical resection with intraoperative frozen margin analysis, and the planned reconstruction was performed in a single anesthetic. RESULTS: = 0.007) were associated with local recurrence. Intraoperative margins were negative in 103 (92%) of patients, 1 of which was positive on final permanent section. There were nine cases of microscopically positive margins, of which seven underwent immediate re-excision to a negative margin. The accuracy of frozen margin assessment for myxofibrosarcoma was between 92.92 and 98.23%. All patients underwent reconstruction at the time of resection, with 19% needing an additional procedure, most commonly due to a wound complication (12%). CONCLUSIONS: Multidisciplinary single-stage excision with intraoperative frozen margin assessment and soft-tissue r...