Clinical practice guidelines for the management of non-functioning advanced GEP-NENs: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology (AIOM) in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET)

作者：Francesca Spada, Fabio Gelsomino, Maria Rinzivillo, Michela Cinquini, Veronica Andrea Fittipaldo, Angelo Tralongo, Ivan Moschetti, Manuela Albertelli, Valentina Ambrosini, Vito Amoroso, Lorenzo Antonuzzo, Giuseppe Badalamenti, Emilio Bajetta, S. Baldari, Marco Barberis, Alfredo Berruti, E Bertani, Guido Bonomo, Lisa Bodei, Roberto Buzzoni, Maria Pia Brizzi, Davide Campana, Gabriele Capurso, Riccardo Casadei, Maurizio Castellano, Sara Cingarlini, Mauro Cives, Annamaria Colao, Jorgelina Coppa, Nadia Cremonini, Maria Vittoria Davì, C.G. De Angelis, Filippo de Braud, Riccardo De Robertis, Antongiulio Faggiano, Massimo Falconi, Matteo Fassan, Piero Ferollà, Diego Ferone, Angelina Filice, Francesco Fiore, Luigi Funicelli, Vincenza Granata, Dario Giuffrida, Chiara Maria Grana, Franco Grimaldi, Toni Ibrahim, Anna La Salvia, Andrea Laghi, Gabriele Luppi, Marco Maccauro, Riccardo Marconcini, Sara Massironi, Vincenzo Mazzaferro, Elettra Merola, Massimo Milione, Roberta Modica, S Ortolani, M Papotti, Stefano Partelli, Giuseppe Pelosi, Sara Pusceddu, Valeria Ramundo, D. Ravizza, Paola Razzore, Giuseppe Reimondo, Claudio Ricci, Guido Rindi, Francesca Rizzo, Roberta Rossi, Salvatore Tafuto, Guido Alberto Massimo Tiberio, Annibale Versari, R. Vigorito, Maria Chiara Zatelli, M. Di Maio, F. Perrone, Saverio Cinieri, Francesco Panzuto, Nicola Fazio · 发表于：ESMO Open · 年份：2025 · DOI：10.1016/j.esmoop.2025.105878 · 被引用次数：3 · 研究领域：Neuroendocrine Tumor Research Advances、Lung Cancer Research Studies、Thyroid Cancer Diagnosis and Treatment

Neuroendocrine neoplasms (NENs) of the gastroenteropancreatic (GEP) tract represent a rare and heterogeneous group of malignancies. They are distinguished into well-differentiated and poorly differentiated neoplasms, with clinical behavior ranging from relatively indolent to fast-growing, respectively. Surgery is the curative option for localized disease, especially in well-differentiated neoplasms, while various systemic therapies are approved and clinically available for advanced disease. However, considering the complexity of these malignancies, the choice of therapeutic strategy must take into account multiple factors, such as histological diagnosis, primary site, extent of disease, evolution features, functional status, patients and treatment characteristics, treatment availability, and safety profile. A multidisciplinary approach dedicated to NENs and conducted by experienced teams is therefore strongly recommended. Since 2013, the Italian Association of Medical Oncology (AIOM), in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET), has produced guidelines using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach for assessing the certainty of evidence. This updated version (2024) summarized the main diagnostic and therapeutic decision-making processes on specific topics selected by a panel of experts from the AIOM, ITANET, and other national scientific societies with the aim of guiding clinicians in the d...