Conductive Covalent Organic Frameworks as Chemiresistive Sensor Arrays for the Detection and Differentiation of Gasotransmitters

作者：Georganna Benedetto, Robert M. Stolz, Zheng Meng, Joseph Y. M. Chan, Elissa O. Shehayeb, Colin T. Morrell, Gbenga Fabusola, Nikolaus Elsaesser, Cory M. Simon, Katherine A. Mirica · 发表于：Journal of the American Chemical Society · 年份：2025 · DOI：10.1021/jacs.5c11454 · 被引用次数：15 · 研究领域：Covalent Organic Framework Applications、Gas Sensing Nanomaterials and Sensors、Advanced Chemical Sensor Technologies

High Resolution Image Download MS PowerPoint Slide This paper describes a chemiresistive sensor array using four structurally analogous, but chemically distinct, conductive covalent organic frameworks (COFs) (M-COF-DC-8, M = Fe, Co, Ni, and Cu) capable of detecting and differentiating four important gaseous analytes: nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H 2 S), and ammonia (NH 3 ). The COFs were synthesized from the condensation of 2,3,9,10,16,17,23,24-octaamino-metallophthalocyanine precursors with pyrenetetraone linkers resulting in chemically robust and electrically conductive materials. Chemiresistive sensing experiments, together with machine learning to parse the response pattern of the sensor array, show that the M-COF-DC-8 (M = Fe, Co, Ni, Cu) materials can detect and differentiate this suite of oxidizing and reducing gases at parts-per-million concentrations, with theoretical limits of detection (LOD) in the parts-per-billion range in dry N 2 . Importantly, the COF array containing M-COF-DC-8 (M = Co, Ni, Cu) retains its ability to detect and differentiate these analytes in air and humidity under low power consumption. Spectroscopic investigations reveal that the synthetic control over the identity of the metallophthalocyanine core efficiently tunes material–analyte interactions and, therefore, emergent device performance. The use of highly tunable COFs as the active material in sensor arrays enables low-power, sensitive, and real-time gas detec...