Acute ataxia in children: etiological spectrum and clinical characteristics

作者：Qing Zhao, Chao Gao, Lihui Wang, Chong Liu, Suzhen Sun, Baoguang Li · 发表于：Frontiers in Pediatrics · 年份：2025 · DOI：10.3389/fped.2025.1613558 · 被引用次数：2 · 研究领域：Autoimmune Neurological Disorders and Treatments、Electrolyte and hormonal disorders、Genetic Neurodegenerative Diseases

Background: Acute ataxia is one of the most common movement disorders in children, characterized by complex etiologies, some of which may lead to disability or life-threatening complications. Early diagnosis and intervention are therefore crucial. Objective: This study aimed to investigate the etiological spectrum and clinical characteristics of children presenting with acute ataxia as the initial symptom. Methods: A retrospective analysis was conducted on children hospitalized at Hebei Children's Hospital between January 2018 and December 2024, all of whom exhibited acute ataxia as the primary manifestation. Clinical data, including etiology, age distribution, and laboratory findings, were systematically reviewed and analyzed. Results: A total of 257 children were included, with a male-to-female ratio of 1.14:1 and a median age of onset of 3 years (range: 10 months to 14 years). Initial screening of 315 records identified 58 patients for exclusion. Etiologies varied by age: infants/toddlers (0-3 years) showed acute postinfectious cerebellar ataxia (APCA, 66%), drug intoxication (14%), and acute disseminated encephalomyelitis (ADEM, 8%); preschoolers (4-6 years) had APCA (63%), ADEM (14%), and acute cerebellitis (AC, 8%); school-aged children (7-14 years) presented APCA (48%), AC (21%), and drug intoxication (14%). AC patients exhibited later onset, longer duration from symptom onset to hospital presentation, and more frequent neurological symptoms (encephalopathy, headache, ...