Machine learning-based prediction of metabolic dysfunction-associated steatotic liver disease using National Health and Nutrition Examination Survey (NHANES) data

作者：Yong Zhang, Xiang Liu, Xingqiang Zhang, Yangfan Fei, Xiaoxu Li · 发表于：PLoS ONE · 年份：2025 · DOI：10.1371/journal.pone.0335656 · 被引用次数：2 · 研究领域：Liver Disease Diagnosis and Treatment、Artificial Intelligence in Healthcare、Diet and metabolism studies

OBJECTIVE: With the global increase in obesity rates and lifestyle changes, metabolic dysfunction-associated steatotic liver disease (MASLD) has become a prevalent chronic liver disorder, affecting approximately 25% of the global population. This disease can progress to cirrhosis and liver cancer, posing a significant threat to public health. To facilitate early diagnosis and intervention, this study aims to develop an efficient and reliable prediction model for MASLD using machine learning algorithm. METHODS: This study included 9,232 participants aged 20 years and older from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). After excluding individuals with frequent alcohol consumption, hepatitis B/C infection, those lacking liver ultrasound examinations, and samples with missing data, a total of 2,460 subjects were ultimately included. The dataset was split into training and testing sets in an 80:20 ratio. Five machine learning algorithms-XGBoost, Random Forest (RF), and Logistic Regression (LR), among others-were utilized to build prediction models, while Recursive Feature Elimination (RFE) was employed to identify key predictive factors. RESULTS: Comparison of the five algorithms revealed that the XGBoost algorithm performed the best. Twelve key features were selected through Recursive Feature Elimination (RFE), and the model achieved an AUC of 0.8740 on the testing set, demonstrating excellent predictive accuracy and discriminative ability. SHAP pl...