Functional requirements for guided bone regeneration/guided tissue regeneration membrane design: Progress and challenges

作者：Huilu Zhan, Ruijianghan Shi, Haohao Ni, Haiyan Li, Changyong Yuan, Kaili Lin, Anton Sculean, Richard J. Miron · 发表于：Periodontology 2000 · 年份：2025 · DOI：10.1111/prd.70019 · 被引用次数：8 · 研究领域：Periodontal Regeneration and Treatments、Bone Tissue Engineering Materials、Oral microbiology and periodontitis research

Guided tissue regeneration (GTR) and guided bone regeneration (GBR) membranes are critical for reconstructing periodontal/bone defects, but existing membranes face limitations in osteogenic potential, antibacterial efficacy, degradation kinetics, mechanical stability, and immunomodulation within the complex oral microenvironment. This review aims to explore cellular interactions between alveolar bone regenerative cells and GBR/GTR membranes, membrane design strategies based on biological functions, and advancements in material engineering to overcome current clinical challenges. A comprehensive search strategy was implemented across PubMed, Scopus, Web of Science databases, as well as clinical trials registers. Data pertinent to membrane synthetic methodology, biological behavior, tissue regeneration outcomes were retrieved from the original studies. A qualitative assessment was performed. Overall, ideal GBR/GTR membranes must meet several functional requirements: (i) Clinical necessities include biocompatibility, selective permeability for nutrient exchange, and clinical operability. GTR aims to create and maintain a stable isolated space to protect blood clots, thereby enabling blood clots and the newly formed tissue to effectively block the migration of epithelial cells. GBR demands rigid space maintenance to resist mucosal compression in edentulous ridges, with greater emphasis on mechanical stability for large bone defects. Degradation kinetics must align with slower bon...