Perspective Chapter: Cross-Talk between Genetics and Biochemistry in the Pathogenesis of Hepatic Steatosis

作者：Mete Ucdal, Başak Çeltikçi · 发表于：IntechOpen eBooks · 年份：2025 · DOI：10.5772/intechopen.1011511 · 研究领域：Inflammasome and immune disorders、Cell death mechanisms and regulation、Liver Disease Diagnosis and Treatment

Hepatic steatosis development involves intricate interactions between genetic susceptibility and biochemical pathway dysregulation. This chapter examines the molecular foundations of hepatocellular lipid accumulation, focusing on metabolic networks and cell death mechanisms. Genetic polymorphisms in lipid regulatory genes (PNPLA3, TM6SF2, and MBOAT7) significantly influence metabolic enzyme expression patterns. Central biochemical processes examined include de novo lipogenesis, β-oxidation impairment, and triglyceride export dysfunction. Particular emphasis is placed on ferrinophagy—a specialized autophagic process regulating iron homeostasis—and its relationship to oxidative stress in steatotic hepatocytes. Further analysis explores how metabolic death pathways, including pyroptosis and necroptosis, contribute to disease progression and potential therapeutic targeting opportunities.