Short-term and long-term effects of sevoflurane inhalation vs propofol total intravenous anesthesia in gastrectomy for gastric cancer

作者：Zhi Wang, Jiwen Cheng, Kuai-Yun Yu · 发表于：World Journal of Gastrointestinal Oncology · 年份：2025 · DOI：10.4251/wjgo.v17.i11.109375 · 被引用次数：2 · 研究领域：Cancer, Stress, Anesthesia, and Immune Response、Anesthesia and Sedative Agents、Anesthesia and Pain Management

BACKGROUND Gastric cancer is a major global health issue, and the perioperative period critically influences patient outcomes. The different effects of sevoflurane inhalation anesthesia and propofol total intravenous anesthesia on intraoperative stability, postoperative complications, and long-term oncologic outcomes in patients with gastric cancer undergoing radical gastrectomy remain unclear. AIM To compare the effects of sevoflurane inhalation anesthesia and propofol total intravenous anesthesia on clinical outcomes, including intraoperative indicators, postoperative complications, adverse effects, pain scores, and survival. METHODS This single-center retrospective cohort study included 204 patients who underwent radical gastrectomy for gastric cancer from February 2019 to December 2022. Patients were assigned to either the sevoflurane group (n = 103) or the propofol group (n = 101) based on intraoperative anesthetic regimen. Standardized protocols for anesthesia management, intraoperative monitoring, and postoperative analgesia were applied. Baseline characteristics; intraoperative metrics; adverse events; complications; Visual Analog Scale (VAS) scores at 2, 4, 6, 24, and 48 hours; and survival outcomes were retrospectively collected. Group comparisons were performed using χ 2 for categorical variables, t test for continuous variables, and Kaplan-Meier analysis for survival outcomes. RESULTS Baseline demographic and clinical characteristics were similar between groups. N...