Synergistic Photocatalysis of Acridinium Salts and Pyridine N -Oxides for α-Aminoalkylation with N -Methylsulfonamides

作者：Wumeng Yang, Zhichao Zhang, Zi Yang, Xi Chen, Xi Chen, Lipeng Qiao, Xiaolan Chen, Xiaolan Chen, Kai Sun, Lingbo Qu, Bing Yu · 发表于：The Journal of Organic Chemistry · 年份：2025 · DOI：10.1021/acs.joc.5c01813 · 被引用次数：48 · 研究领域：Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques、Radical Photochemical Reactions

This study presents a synergistic photocatalytic method using acridinium salts and pyridine N -oxides for the Giese reaction between N -methylsulfonamides and olefins, which utilizes N -methylsulfonamides as α-aminoalkylating reagents. Notable features of this approach include mild reaction conditions, excellent atom economy, good site selectivity, a broad substrate scope, and the ability to enable postmodification of complex drug fragments.