Glymphatic System Dysfunction in Thyroid‐Associated Ophthalmopathy: A Multimodal MRI Study

作者：Lijie Zhang, Jiaqi Yao, Yiming Qi, Yongheng Luo, Jun Liu · 发表于：CNS Neuroscience & Therapeutics · 年份：2025 · DOI：10.1111/cns.70650 · 被引用次数：3 · 研究领域：Ophthalmology and Eye Disorders、Cerebrospinal fluid and hydrocephalus、Head and Neck Anomalies

OBJECTIVE: To investigate glymphatic system (GS) alterations in thyroid-associated ophthalmopathy (TAO) patients and their links to clinical biomarkers, with the aim of understanding underlying mechanisms and potential therapeutic strategies. METHODS: This study included 28 active patients (AP), 25 inactive patients (IP) with TAO, and 37 healthy controls (HC), matched for age, sex, and educational level. Glymphatic function was evaluated using choroid plexus volume (CPV), diffusion tensor imaging along the perivascular space (DTI-ALPS) index, and coupling between global blood-oxygen-level-dependent signals and cerebrospinal fluid signals (gBOLD-CSF coupling). General linear regression analysis was conducted to explore the relationships between the GS and clinical parameters. RESULTS: Significant differences were found in the ALPS index between the patient groups and the HC. Both the left (ALPS_L) and right (ALPS_R) ALPS indices, as well as the average ALPS index, were significantly lower in the AP and IP groups than in the HC (p < 0.01). The overall difference across all three groups was also significant (p < 0.01). However, no significant differences were observed between the AP and IP groups. However, no significant differences in CPV were observed between either the AP or IP group and the HC. Both the AP and IP groups exhibited lower gBOLD-CSF coupling than the HC (p = 0.001; p = 0.013). Significant correlations existed between GS function and clinical parameters in both g...