The global burden of motor neuron disease: a systematic and additional analysis of global burden disease study 2021

作者：Yiqi Chen, Changyuan Yu, Zheng-Qi Song, Q Y Lu, Morgan Jones, Muhammad Nisar, Jiangtao Luo, Yong Xiao, Jialiang Lin, Qiu Heng, Jiajie Lu, Xiangxiang Pan, Haiming Jin, Xueqin Bai · 发表于：Orphanet Journal of Rare Diseases · 年份：2025 · DOI：10.1186/s13023-025-04084-6 · 被引用次数：2 · 研究领域：Amyotrophic Lateral Sclerosis Research、Neurogenetic and Muscular Disorders Research、Hereditary Neurological Disorders

BACKGROUND: The last 30 years witnessed significant changes in motor neuron disease (MND) epidemiology. Our study aims to explore the trends and inequality of MND, and predict future changes to 2046. METHODS: We used Global Burden of Disease (GBD) 2021 data and methodologies (including trends, decomposition, inequality, frontier, and prediction) to describe the disease burden of MND of incidence, prevalence, deaths, and disability-adjusted life-years (DALYs). RESULTS: The case number of incidence, prevalence, deaths and DALYs illustrated an upward trend, however, the age-standardized rate (ASR) for these metrics remained stable. There is substantial variability in MND burden across regions and countries, with higher ASR observed in high sociodemographic index (SDI) regions, particularly the United States, Finland, and the United Kingdom. Gender and age differences also contribute to the disease burden, with males and older populations exhibiting higher incidence rates. The age-period-cohort analysis revealed distinct temporal trends of DALYs across age, period, and birth cohort. Decomposition analysis revealed population aging and growth are critical drivers of the increasing burden. Additionally, the cross-country inequality analysis indicates widening disparities in MND burden, particularly in high SDI regions, from 1990 to 2021. Forecasts for 2046 suggest that while the number of deaths and DALYs may decrease, the incidence and prevalence of MND are expected to continue ri...