Two New Chromone Derivatives from a Marine Algicolous Fungus Aspergillus versicolor GXIMD 02518 and Their Osteoclastogenesis Inhibitory Activity

作者：Xin Qi, Zongjin Li, Miaoping Lin, Humu Lu, Shuai Peng, Huangxue Qin, Yonghong Liu, Chenghai Gao, Xiaowei Luo · 发表于：Marine Drugs · 年份：2025 · DOI：10.3390/md23110429 · 被引用次数：2 · 研究领域：Bone Metabolism and Diseases、Microbial Natural Products and Biosynthesis、Cytokine Signaling Pathways and Interactions

Two new chromone derivatives, cnidimols I and J (1 and 2), together with ten known aromatic derivatives (3–12), were isolated from the Beibu Gulf algicolous fungus Aspergillus versicolor GXIMD 02518. Their structures were determined by comprehensive physicochemical and spectroscopic data interpretation. The absolute configurations of 1 and 2 were accomplished by ECD calculations and X-ray diffraction analysis. Compound 1 was obtained as a pair of enantiomers, which were separated by chiral-phase HPLC analysis. Notably, 3,7-dihydroxy-1,9-dimethyldibenzofuran (6) displayed significant inhibition in LPS-induced NF-κB luciferase activity in RAW 264.7 macrophages, which further inhibited RANKL-induced osteoclast differentiation without cytotoxicity in bone marrow macrophage cells.