IMG-117. Characterization of recurrent IDH-mutant glioma using multiparametric1H/Hyperpolarized-13C MRI and histopathological analysis

作者：Xiaolong Xing, Adam Autry, Tracy Luks, Marisa Lafontaine, Devika Nair, Janine Lupo, Joanna J. Phillips, Javier Villanueva-Meyer, Hervey-Jumper Shawn, Mitchel S. Berger, Nancy Ann Oberheim Bush, Daniel B. Vigneron, Susan M. Chang, Yan Li · 发表于：Neuro-Oncology · 年份：2025 · DOI：10.1093/neuonc/noaf201.1196 · 被引用次数：1 · 研究领域：Glioma Diagnosis and Treatment、Advanced NMR Techniques and Applications、Advanced MRI Techniques and Applications

Abstract BACKGROUND Isocitrate dehydrogenase (IDH)-mutant gliomas demonstrate metabolic reprogramming and remain challenging to assess using conventional MRI alone. 1H MR spectroscopic imaging (MRSI) of steady-state metabolism and real-time hyperpolarized carbon-13 (HP-13C) MRI of dynamic metabolism are of interest for evaluating response to treatment. This study aimed to improve characterization of IDH-mutant glioma through multimodal analysis of 1H/HP-13C MRI and histopathology in patients before surgery for suspected tumor progression. METHOD Six IDH-mutant glioma patients (1F/5M, 46.2±7.6 years; 5 astrocytoma [2 grade 2, 1 grade 3, 2 grade 4], 1 grade 3 oligodendroglioma) received multiparametric 1H/HP-13C MR examinations on a 3-Tesla MR scanner before surgery. All patients had confirmed tumor progression; one grade 2 underwent malignant transformation to grade 3. During surgery, 21 tissue samples were collected with imaging coordinates and analyzed for histopathology. Imaging parameters were reprocessed to center on recorded biopsy locations to provide normalized apparent diffusion coefficients (nADC)/relative cerebral blood volume (nCBV)/relative cerebral blood flow (nCBF)/peak height (nPH), %recovery, choline-to-N-acetylaspartate index (CNI), pyruvate-to-lactate conversion rate (kPL), ratios of lactate-to-pyruvate (Lac/Pyr) and bicarbonate-to-pyruvate (Bic/Pyr). Tissue samples were assessed for treatment effects, blood vessels (BV), carbonic anhydrase 9 (CA9), and Ki-6...