The Italian Society for Rheumatology guidelines for the treatment of patients with rheumatoid arthritis and interstitial lung disease

作者：Chiara Crotti, Nicola Ughi, Carlo Alberto Scirè, Fabrizio Luppi, Fabiola Atzeni, Silvia Laura Bosello, Roberto Caporali, Marina Carotti, Greta Carrara, Giulia Cassone, L. Cavagna, Lucia Dardani, Enrico De Lorenzis, Gian Luca Erre, Angelo Fassio, Roberto Gerli, Sergio Harari, Florenzo Iannone, Gianpiero Landolfi, Andrea Lo Monaco, Silvia Mancuso, Marco Matucci‐Cerinic, Maria Antonietta Mazzei, Venerino Poletti, Massimo Radin, Davide Rozza, Fausto Salaffi, Stefano Salvioli, Gian Domenico Sebastiani, Silvia Tonolo, Carlo Vancheri, Andreina Manfredi, Marco Sebastiani · 发表于：Reumatismo · 年份：2025 · DOI：10.4081/reumatismo.2025.1865 · 被引用次数：2 · 研究领域：Rheumatoid Arthritis Research and Therapies、Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis、Spondyloarthritis Studies and Treatments

OBJECTIVE: In the absence of national and European guidelines on the treatment of rheumatoid arthritis (RA) with interstitial lung disease (ILD), the Italian Society of Rheumatology decided to develop national clinical practice guidelines on the management of patients with RA-ILD in accordance with the requirements of the National Guideline System of the National Institute of Health. METHODS: The development process included a systematic review of the available evidence and its adaptability to the Italian context, followed by a consultation with experts in rheumatology, respiratory diseases, radiology, and representatives of the health professions and patients. RESULTS: The panel decided to develop recommendations in three main scenarios. The first section of recommendations is focused on drugs indicated for RA to assess their safety and efficacy in RA-ILD. The second set of recommendations covered the drugs indicated for the treatment of ILD in patients with RA-ILD (to assess their efficacy and safety in patients with RA). The third part of these guidelines dealt with drugs indicated for the treatment of RA-ILD upon first-line failure. Moreover, the lack or absence of scientific evidence in literature on certain topics, such as the value of a multidisciplinary treatment approach and lung transplantation, led to the decision to proceed through expert consensus to develop good clinical practice guidelines. CONCLUSIONS: These guidelines represent a fundamental step towards impr...