Insights into the methyltransferase activity and methylation status of PRDM16 in malignant tumors

作者：Yu Wang, Yuting Wang, Anjia Han · 发表于：Cell Signaling · 年份：2025 · DOI：10.46439/signaling.3.080 · 被引用次数：1 · 研究领域：Epigenetics and DNA Methylation、Cancer-related gene regulation、RNA modifications and cancer

The PRDM16 (PRDI-BF1-interacting and RIZ1-homologous domain 16) participates in a range of biological processes including tumorigenesis. The protein regulates gene transcription through intrinsic chromatin-modifying enzymatic activity or by forming complexes with histone modifications or other nuclear proteins. Accumulating evidence indicates that the methyltransferase activity and its methylation status of PRDM16 had been further studied. Significant advances have been made in elucidating the role and underlying molecular mechanisms of methyltransferase activity and its methylation status of PRDM16 in hematologic tumors and solid tumors. This review focus on the advances of PRDM16 in terms of its methyltransferase activity and methylation status in tumors. Meanwhile, we also discuss the future perspectives of PRDM16 methylation.