Clinical, Radiologic, and Pathologic Associations of Executive Dysfunction in Children With Focal Cortical Dysplasia–Related Epilepsy

作者：Nathan T. Cohen, Hua Xie, Venkata Sita Priyanka Illapani, Sonya M. Leikin, Xiao Li, Ana Moreno Chaza, Chloe A Hooker, L. Gilbert Vezina, Chima Oluigbo, Hayley Loblein, William D. Gaillard, Leigh Sepeta, Madison M. Berl · 发表于：Neurology · 年份：2025 · DOI：10.1212/wnl.0000000000214352 · 被引用次数：4 · 研究领域：Functional Brain Connectivity Studies、Epilepsy research and treatment、Neuroscience and Neuropharmacology Research

BACKGROUND AND OBJECTIVE: Executive dysfunction (ExD) is a common comorbidity of focal epilepsy. Focal cortical dysplasia (FCD) is the most common lesional cause of epilepsy in children. We aimed to investigate clinical, etiologic (pathology), and anatomic vs functional network associations with ExD in FCD-related epilepsy. FCD lesion-network interactions may underlie ExD. The primary analysis was to evaluate whether FCD colocalization to frontoparietal control network or attention networks is associated with ExD. We also evaluated whether FCD type I pathology is associated with ExD because it is reported to be associated with worse intellectual function. METHODS: Patients with FCD were included from retrospective surgical/radiologic databases at Children's National Hospital from January 2000 to January 2022 if they had preoperative neuropsychological testing. FCD colocalization to the Yeo 7-network atlas was determined. Clinical, radiologic, and pathologic factors were evaluated for association with ExD. The primary outcome measure was ExD measured categorically (ExD/Not ExD) and linearly (Behavior Rating Inventory of Executive Function [BRIEF]-Global Executive Composite [GEC] T-score). RESULTS: = 0.006) subscales. These findings were not related to Full Scale IQ. FCD colocalization to attentional network (dorsal or ventral), lobar location, or age seizure onset was not associated with ExD. DISCUSSION: These data demonstrate the importance of lesion-network interaction in ne...