Cellular Senescence in Endometrium: A Pivotal Regulator in Physiological Remodeling and Pathological Disorders

作者：Zi-Yang Yan, Wenjie Zhou, Jiang-Feng Ye, Feng Xie, Chunxue Zhang, Ming‐Qing Li · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.123036 · 被引用次数：12 · 研究领域：Reproductive System and Pregnancy、Endometriosis Research and Treatment、Gynecological conditions and treatments

As a highly dynamic tissue, the endometrium undergoes complex remodeling during the menstrual cycle and pregnancy. Recent studies have revealed that cellular senescence plays a pivotal role in both physiological renewal (e.g., menstrual shedding, decidualization) and pathological disorders (e.g., endometriosis, intrauterine adhesions, thin endometrium) of the endometrium. Under physiological conditions, senescent cells contribute to tissue repair and embryo implantation through precise regulation. However, pathological accumulation of senescent cells drives chronic inflammation, fibrosis, and reproductive dysfunction. Here we aim to summarize the mechanism indicating endometrial senescence and elucidating their pleiotropic roles in both physiological homeostasis and pathological progression, while discussing emerging therapeutic strategies for clinical translation-including senolytics and SASP inhibitors.