Activation of GSDME by all- trans -retinal increases sensitivity to photoreceptor ferroptosis

作者：Bo Yang, Kunhuan Yang, Yuling Chen, Ruitong Xi, Jiahuai Han, Shiying Li, Jingmeng Chen, Yalin Wu · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.114187 · 被引用次数：5 · 研究领域：Ferroptosis and cancer prognosis、Retinal Diseases and Treatments、Retinal Development and Disorders

mice. We found that both GSDME elimination and MitoTEMPO treatment repressed atRAL-induced photoreceptor ferroptosis and retinal atrophy by inactivating the mitoROS-induced oxidative stress. In conclusion, GSDME-mediated photoreceptor ferroptosis is crucial for inducing structural and functional damage of the retina in retinopathies caused by atRAL accumulation, thereby providing new therapeutic insights for the prevention and treatment of STGD1 and dry AMD.